2413603-10-6

2413603-10-6 structure

Name: HDAC6-IN-6
Chemical Name: HDAC6-IN-6
CAS Number: 2413603-10-6
Molecular Formula: C₂₀H₁₅N₃O₂
Molecular Weight: 329.35
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-06-28 13:41:26
Modify Date: 2025-08-27 07:26:15
HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1].

Name	HDAC6-IN-6

Description	HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Neuronal Signaling >> AChE
Target	HDAC6:0.025 ± 0. μM (IC50) HDAC1:0.34 ± 0.0 μM (IC50) HDAC:0.55 ± 0.0 μM (IC50) HDAC9:0.57 ± 0.0 μM (IC50) HDAC7:0.65 ± 0.0 μM (IC50) HDAC5:0.85 ± 0.0 μM (IC50) HDAC3:1.22 ± 0.0 μM (IC50) HDAC2:1.57 ± 0.0 μM (IC50) HDAC4:2.24 ± 0.0 μM (IC50)
In Vitro	HDAC6-IN-6 (compound 6a) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 7.96 and 8 μM, respectively[1]
References	[1]. Tseng HJ, et al. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease. Eur J Med Chem. 2020 Apr 15;192:112193.

Molecular Formula	C₂₀H₁₅N₃O₂
Molecular Weight	329.35