2757182-99-1

2757182-99-1 structure

Name: HIV-1 inhibitor-15
Chemical Name: HIV-1 inhibitor-15
CAS Number: 2757182-99-1
Molecular Formula: C₂₄H₂₀N₆
Molecular Weight: 392.46
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-06-27 08:39:40
Modify Date: 2024-01-12 22:01:12
HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability[1].

Name	HIV-1 inhibitor-15

Description	HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1 (WT):1.7 nM (EC50) HIV-1 (L100I):4 nM (EC50) HIV-1 (K103N):2 nM (EC50) HIV-1 (Y181C):6 nM (EC50) HIV-1 (E138K):9 nM (EC50)
References	[1]. Ding L, et al. Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK. J Med Chem. 2022;65(3):2122-2138.

Molecular Formula	C₂₄H₂₀N₆
Molecular Weight	392.46