HIV-1 inhibitor-15

Modify Date: 2025-08-26 16:05:32

HIV-1 inhibitor-15 Structure
HIV-1 inhibitor-15 structure
Common Name HIV-1 inhibitor-15
CAS Number 2757182-99-1 Molecular Weight 392.46
Density N/A Boiling Point N/A
Molecular Formula C24H20N6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HIV-1 inhibitor-15


HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability[1].

 Names

Name HIV-1 inhibitor-15

 HIV-1 inhibitor-15 Biological Activity

Description HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability[1].
Related Catalog
Target

HIV-1 (WT):1.7 nM (EC50)

HIV-1 (L100I):4 nM (EC50)

HIV-1 (K103N):2 nM (EC50)

HIV-1 (Y181C):6 nM (EC50)

HIV-1 (E138K):9 nM (EC50)

References

[1]. Ding L, et al. Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK. J Med Chem. 2022;65(3):2122-2138.

 Chemical & Physical Properties

Molecular Formula C24H20N6
Molecular Weight 392.46
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