2132412-77-0

2132412-77-0 structure

Name: HIV-1 inhibitor-30
Chemical Name: HIV-1 inhibitor-30
CAS Number: 2132412-77-0
Molecular Formula: C₁₉H₂₀ClN₃O₂
Molecular Weight: 357.83
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-07-02 14:03:59
Modify Date: 2024-09-12 09:41:41
HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS[1].

Name	HIV-1 inhibitor-30

Description	HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	EC50: 40 nM (HIV-1 WT)[1] IC50: 80 nM (HIV-1 RT DNA polymerase)[1]
References	[1]. Xu C,et al. Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root. Eur J Med Chem. 2020 Mar 1;189:112071.

Molecular Formula	C₁₉H₂₀ClN₃O₂
Molecular Weight	357.83