2253119-24-1
2253119-24-1 structure
- Name: KRAS G12C inhibitor 47
- Chemical Name: KRAS G12C inhibitor 47
- CAS Number: 2253119-24-1
- Molecular Formula: C30H28ClFN4O3
- Molecular Weight: 547.02
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2022-07-28 21:10:25
- Modify Date: 2024-01-05 18:27:35
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KRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC50 of 0.172 µM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC50s of 0.046, 69.8 µM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
| Name | KRAS G12C inhibitor 47 |
|---|
| Description | KRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC50 of 0.172 µM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC50s of 0.046, 69.8 µM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
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| Related Catalog | |
| Target |
KRas G12C:0.172 μM (IC50) |
| References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
| Molecular Formula | C30H28ClFN4O3 |
|---|---|
| Molecular Weight | 547.02 |