KRAS G12C inhibitor 47
Modify Date: 2024-01-05 18:27:35
KRAS G12C inhibitor 47 structure
|
Common Name | KRAS G12C inhibitor 47 | ||
|---|---|---|---|---|
| CAS Number | 2253119-24-1 | Molecular Weight | 547.02 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H28ClFN4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KRAS G12C inhibitor 47KRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC50 of 0.172 µM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC50s of 0.046, 69.8 µM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
| Name | KRAS G12C inhibitor 47 |
|---|
| Description | KRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC50 of 0.172 µM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC50s of 0.046, 69.8 µM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
|---|---|
| Related Catalog | |
| Target |
KRas G12C:0.172 μM (IC50) |
| References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
| Molecular Formula | C30H28ClFN4O3 |
|---|---|
| Molecular Weight | 547.02 |