2230873-75-1
2230873-75-1 structure
- Name: KRAS inhibitor-15
- Chemical Name: KRAS inhibitor-15
- CAS Number: 2230873-75-1
- Molecular Formula: C20H17Cl2FN4OS
- Molecular Weight: 451.34
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2022-08-16 21:34:09
- Modify Date: 2024-01-16 12:29:41
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KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC50 of 0.954 µM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC50s of 2.03, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
| Name | KRAS inhibitor-15 |
|---|
| Description | KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC50 of 0.954 µM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC50s of 2.03, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
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| Related Catalog | |
| Target |
KRas G12C:0.954 μM (IC50) |
| References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
| Molecular Formula | C20H17Cl2FN4OS |
|---|---|
| Molecular Weight | 451.34 |