2230873-65-9
2230873-65-9 structure
- Name: KRAS inhibitor-17
- Chemical Name: KRAS inhibitor-17
- CAS Number: 2230873-65-9
- Molecular Formula: C21H18Cl2FN3O2S
- Molecular Weight: 466.36
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2022-07-01 17:58:51
- Modify Date: 2024-01-10 21:58:45
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KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC50 of 3.37 µM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC50s of 9.25, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
| Name | KRAS inhibitor-17 |
|---|
| Description | KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC50 of 3.37 µM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC50s of 9.25, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
|---|---|
| Related Catalog | |
| Target |
KRas G12C:3.37 μM (IC50) |
| References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
| Molecular Formula | C21H18Cl2FN3O2S |
|---|---|
| Molecular Weight | 466.36 |