KRAS inhibitor-17
Modify Date: 2024-01-10 21:58:45
KRAS inhibitor-17 structure
|
Common Name | KRAS inhibitor-17 | ||
|---|---|---|---|---|
| CAS Number | 2230873-65-9 | Molecular Weight | 466.36 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H18Cl2FN3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KRAS inhibitor-17KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC50 of 3.37 µM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC50s of 9.25, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
| Name | KRAS inhibitor-17 |
|---|
| Description | KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC50 of 3.37 µM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC50s of 9.25, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
|---|---|
| Related Catalog | |
| Target |
KRas G12C:3.37 μM (IC50) |
| References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
| Molecular Formula | C21H18Cl2FN3O2S |
|---|---|
| Molecular Weight | 466.36 |