2170347-90-5
2170347-90-5 structure
- Name: LSD1-IN-13 hydrochloride
- Chemical Name: LSD1-IN-13 hydrochloride
- CAS Number: 2170347-90-5
- Molecular Formula: C23H30ClN3O2S
- Molecular Weight: 448.02
- Catalog: Signaling Pathways Epigenetics Histone Demethylase
- Create Date: 2022-08-30 15:51:40
- Modify Date: 2024-01-17 18:03:02
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LSD1-IN-13 hydrochloride (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 hydrochloride can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 hydrochloride induces differentiation of AML (acute myeloid leukemia) cell lines[1].
| Name | LSD1-IN-13 hydrochloride |
|---|
| Description | LSD1-IN-13 hydrochloride (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 hydrochloride can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 hydrochloride induces differentiation of AML (acute myeloid leukemia) cell lines[1]. |
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| Related Catalog | |
| Target |
IC50: 24.43 ± 1.08 nM (LSD1), 5.00 ± 0.28 μM (LSD2), >100 μM (MAO-A), >100 μM (MAO-B)[1] |
| In Vitro | LSD1-IN-13 hydrochloride (compound 7e) shows good selectivity over LSD2 (205-fold) and MAOs (>4000-fold)[1]. LSD1-IN-13 hydrochloride shows potent and selective antiproliferative activity in MV-4-11, with an IC50 of 1.36 μM[1]. |
| In Vivo | LSD1-IN-13 hydrochloride (compound 7e) (MV-4-11 xenograft mice, 0-20 mg/kg, Orally, daily for 15 days) suppresses tumor growth significantly in a dose-dependent manner[1]. |
| References |
| Molecular Formula | C23H30ClN3O2S |
|---|---|
| Molecular Weight | 448.02 |