2413308-63-9

2413308-63-9 structure

Name: LXRβ agonist-3
Chemical Name: LXRβ agonist-3
CAS Number: 2413308-63-9
Molecular Formula: C₃₀H₃₃N₃O₆S
Molecular Weight: 563.66
Catalog: Signaling Pathways Metabolic Enzyme/Protease LXR
Create Date: 2022-06-29 06:18:36
Modify Date: 2024-01-10 19:43:50
LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC50 of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC50 of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma[1].

Name	LXRβ agonist-3

Description	LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC50 of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC50 of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> LXR
Target	EC50: 0.095 ± 0.012 μM (LXRβ) 0.277 ± 0.066 μM (LXRα)[1]
In Vivo	LXRβ agonist-3 (compound 4-13) (BALB/c mice, 50 mg/kg, IP, daily for 15 days) significantly reduces glioblastoma tumor growth[1].
References	[1]. Chen H, Chen Z, Zhang Z, Li Y, Zhang S, Jiang F, Wei J, Ding P, Zhou H, Gu Q, Xu J. Discovery of new LXRβ agonists as glioblastoma inhibitors. Eur J Med Chem. 2020 May 15;194:112240.

Molecular Formula	C₃₀H₃₃N₃O₆S
Molecular Weight	563.66