128294-71-3

128294-71-3 structure

Name: Metallo-β-lactamase-IN-3
Chemical Name: Metallo-β-lactamase-IN-3
CAS Number: 128294-71-3
Molecular Formula: C₁₀H₁₁NO₃S
Molecular Weight: 225.26
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-07-06 09:21:03
Modify Date: 2024-01-06 12:39:34
Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-3 shows high activity against VIM-1 and NDM-1, with IC50 of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7[1].

Name	Metallo-β-lactamase-IN-3

Description	Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-3 shows high activity against VIM-1 and NDM-1, with IC50 of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 0.6 ± 0.0 μM (VIM-1), 1.0 ± 0.4 μM (NDM-1), > 10 μM (IMP-7)[1]
References	[1]. Kaya C, et al. N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases. J Med Chem. 2022 Mar 10;65(5):3913-3922.

Molecular Formula	C₁₀H₁₁NO₃S
Molecular Weight	225.26