2413974-52-2

2413974-52-2 structure

Name: Mt KARI-IN-2
Chemical Name: Mt KARI-IN-2
CAS Number: 2413974-52-2
Molecular Formula: C₁₄H₁₁N₅O₄S₂
Molecular Weight: 377.40
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-07-01 17:27:10
Modify Date: 2024-01-14 11:34:47
Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL)[1].

Name	Mt KARI-IN-2

Description	Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Ki: 2.02 μM (Mtb KARI)[1]
References	[1]. Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.

Molecular Formula	C₁₄H₁₁N₅O₄S₂
Molecular Weight	377.40