Mt KARI-IN-2

Modify Date: 2024-01-14 11:34:47

Mt KARI-IN-2 structure	Common Name	Mt KARI-IN-2
	CAS Number	2413974-52-2	Molecular Weight	377.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₁N₅O₄S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Mt KARI-IN-2

Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL)[1].

Name	Mt KARI-IN-2

Description	Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Ki: 2.02 μM (Mtb KARI)[1]
References	[1]. Krishna VS, et al. Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors. Eur J Med Chem. 2020;193:112178.

Molecular Formula	C₁₄H₁₁N₅O₄S₂
Molecular Weight	377.40

Mt KARI-IN-2

Use of Mt KARI-IN-2

Names

Mt KARI-IN-2 Biological Activity

Chemical & Physical Properties