2395016-49-4

2395016-49-4 structure

Name: P2Y2R/GPR17 antagonist 1
Chemical Name: P2Y2R/GPR17 antagonist 1
CAS Number: 2395016-49-4
Molecular Formula: C₁₉H₁₃ClN₂O₆S
Molecular Weight: 432.83
Catalog: Signaling Pathways GPCR/G Protein P2Y Receptor
Create Date: 2022-06-26 15:49:50
Modify Date: 2024-01-11 18:31:57
P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes[1].

Name	P2Y2R/GPR17 antagonist 1

Description	P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> P2Y Receptor Research Areas >> Inflammation/Immunology
Target	IC50: 1.67 µM (GPR17), 3.17 µM (P2Y2R)[1]
References	[1]. Pillaiyar T, et al. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur J Med Chem. 2020 Jan 15;186:111789.

Molecular Formula	C₁₉H₁₃ClN₂O₆S
Molecular Weight	432.83