2497686-68-5

2497686-68-5 structure

Name: RMS5
Chemical Name: RMS5
CAS Number: 2497686-68-5
Molecular Formula: C₃₅H₃₈N₂O₅S
Molecular Weight: 598.75
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-11 11:15:38
Modify Date: 2024-04-06 14:04:51
RMS5, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS5 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS5 slightly diminishes the expression of the anti-apoptotic Bcl-2 family proteins Bcl-XL and Mcl-1. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS5 has strong anticancer property[1].

Name	RMS5

Description	RMS5, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS5 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS5 slightly diminishes the expression of the anti-apoptotic Bcl-2 family proteins Bcl-XL and Mcl-1. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS5 has strong anticancer property[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
References	[1]. RamonaSchütz, et al. Synthesis, biological evaluation and toxicity of novel tetrandrine analogues. Eur J Med Chem. 2020 Dec 1;207:112810.

Molecular Formula	C₃₅H₃₈N₂O₅S
Molecular Weight	598.75