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1619269-19-0

1619269-19-0 structure

1619269-19-0 structure

Name: Tau-aggregation-IN-1
Chemical Name: Tau-aggregation-IN-1
CAS Number: 1619269-19-0
Molecular Formula: C₂₈H₃₇N₅O₂S
Molecular Weight: 507.69
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2022-06-27 09:59:32
Modify Date: 2026-07-01 13:07:34
Tau-aggregation-IN-1 (Compound D-519) is a tau441 protein aggregation inhibitor with an IC50 of 21 µM. Tau-aggregation-IN-1 is also a dopamine D2 and D3 receptor agonist[1].

Name	Tau-aggregation-IN-1
Synonyms	[1,1'-Biphenyl]-3,4-diol, 4'-[4-[2-[[(6R)-2-amino-4,5,6,7-tetrahydro-6-benzothiazolyl]propylamino]ethyl]-1-piperazinyl] Tau-agegation-IN-1

Description	Tau-aggregation-IN-1 (Compound D-519) is a tau441 protein aggregation inhibitor with an IC50 of 21 µM. Tau-aggregation-IN-1 is also a dopamine D2 and D3 receptor agonist[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 Receptor D3 Receptor
References	[1]. Iva Ziu, et al. The multifunctional dopamine D2/D3 receptor agonists also possess inhibitory activity against the full-length tau441 protein aggregation. Bioorg Med Chem. 2020 Sep 15;28(18):115667.

Molecular Formula	C₂₈H₃₇N₅O₂S
Molecular Weight	507.69

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