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184579-57-5

184579-57-5 structure

184579-57-5 structure

Name: Tubulin inhibitor 27
Chemical Name: Tubulin inhibitor 27
CAS Number: 184579-57-5
Molecular Formula: C₂₁H₁₉NO₄
Molecular Weight: 349.38
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2022-08-18 14:55:53
Modify Date: 2024-04-02 19:57:10
Tubulin inhibitor 27 (DYT-1) is a tubulin polymerisation inhibitor with an IC50 of 25.6 µM. Tubulin inhibitor 27 shows anti-angiogenesis and antitumor activities[1].

Name	Tubulin inhibitor 27

Description	Tubulin inhibitor 27 (DYT-1) is a tubulin polymerisation inhibitor with an IC50 of 25.6 µM. Tubulin inhibitor 27 shows anti-angiogenesis and antitumor activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	IC50: 25.6 µM (Tubulin polymerisation)[1]
In Vitro	Tubulin inhibitor 27 (DYT-1) shows anti-proliferation activity with IC50 values of 6.2 µM and 7.9 µM against K562 and Jurkat, respectively[1].
In Vivo	Tubulin inhibitor 27 (DYT-1) shows anti-angiogenesis activity in Zebrafish with an IC50 of 38.4 µM[1].
References	[1]. Yao Y, et al. Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):652-665.

Molecular Formula	C₂₁H₁₉NO₄
Molecular Weight	349.38

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