2419951-75-8
2419951-75-8 structure
- Name: ADG-2e
- Chemical Name: ADG-2e
- CAS Number: 2419951-75-8
- Molecular Formula: C42H67N11O4
- Molecular Weight: 790.05
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2022-08-18 11:48:18
- Modify Date: 2024-09-12 15:02:38
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ADG-2e is a potent antibacterial agent with MICs of 16, 4, 2, and 2 μg/mL for E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], B.subtilis [KCTC 3068], and S. aureus [KCTC 1621], respectively. ADG-2e shows anti-metastatic activity against breast cancer cells[1].
| Name | ADG-2e |
|---|
| Description | ADG-2e is a potent antibacterial agent with MICs of 16, 4, 2, and 2 μg/mL for E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], B.subtilis [KCTC 3068], and S. aureus [KCTC 1621], respectively. ADG-2e shows anti-metastatic activity against breast cancer cells[1]. |
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| Related Catalog | |
| In Vitro | ADG-2e (1-64 μg/mL, 22 hours) exhibits twice the antibacterial activity compared to other antibiotics in methicillin-resistant S. aureus (MRSA) or multidrug-resistant P. aeruginosa (MDRPA) [1]. ADG-2e (0-60 μg/mL, 2 hours) shows only slight hemolysis with increasing concentration[1]. ADG-2e (0-100 μM, 24 hours) does not inhibit the proliferation of MDA-MB-231 cells but has a role in the migration of cancer cells by inserting into the surface of them and affecting cell motility[1]. ADG-2e (0-40 μM, 6 hours) causes actin reorganization to promote its multiple lamellar structures formation[1]. Cell Cytotoxicity Assay[1] Cell Line: Sheep red blood cells (sRBCs) Concentration: 0-60 μg/mL Incubation Time: 2 hours Result: Showed any hemolysis until 16 μg/mL and showed slight hemolysis at 32 μg/mL. Cell Proliferation Assay[1] Cell Line: Metastatic breastcancer cell line MDA-MB-231 Concentration: 0-100 μM Incubation Time: 24 hours Result: No significant inhibitory effect on the proliferation of MDA-MB-231 cells. Immunofluorescence[1] Cell Line: Metastatic breastcancer cell line MDA-MB-231 Concentration: 0-40 μM Incubation Time: 6 hours Result: Showed an increase in actin lamellipodium generation. |
| References |
| Molecular Formula | C42H67N11O4 |
|---|---|
| Molecular Weight | 790.05 |