2459489-51-9

2459489-51-9 structure

2459489-51-9 structure

Name: AKT-IN-13
Chemical Name: AKT-IN-13
CAS Number: 2459489-51-9
Molecular Formula: C₂₄H₃₁ClN₆O₂
Molecular Weight: 470.99
Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
Create Date: 2022-08-14 11:36:38
Modify Date: 2024-01-16 22:22:40
AKT-IN-13 (compound 4b) is a potent Akt inhibitor with IC50s of 1.6 nM, 2.4 nM and 0.3 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-13 can be used for researching anticancer[1].

Name	AKT-IN-13

Description	AKT-IN-13 (compound 4b) is a potent Akt inhibitor with IC50s of 1.6 nM, 2.4 nM and 0.3 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-13 can be used for researching anticancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Akt1:1.6 nM (IC50) Akt2:2.4 nM (IC50) Akt3:0.3 nM (IC50)
In Vitro	AKT-IN-13 (compound 4b) displays good potency in the LNCap cell line with an IC50 value of 103 nM and a high free fraction with 51.3% human plasma protein binding (PPB)[1].
References	[1]. Ma C, et al. Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors. J Med Chem. 2022 Jun 23;65(12):8144-8168.

Molecular Formula	C₂₄H₃₁ClN₆O₂
Molecular Weight	470.99