2418579-17-4
2418579-17-4 structure
- Name: Anti-melanoma agent 1
- Chemical Name: Anti-melanoma agent 1
- CAS Number: 2418579-17-4
- Molecular Formula: C28H28N2O2
- Molecular Weight: 424.53
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-09-02 18:41:29
- Modify Date: 2024-01-16 13:40:46
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Anti-melanoma agent 1 (Compound 5m) is an anti-melanoma agent and induces cell apoptosis[1].
| Name | Anti-melanoma agent 1 |
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| Description | Anti-melanoma agent 1 (Compound 5m) is an anti-melanoma agent and induces cell apoptosis[1]. |
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| Related Catalog | |
| In Vitro | Anti-melanoma agent 1 (Compound 5m) (0-100 μM, 48 h) shows antiproliferative activity against melanoma cells[1]. Anti-melanoma agent 1 (0-10 μM) inhibits colony formation in SK-MEL-28[1]. Anti-melanoma agent 1 (1 and 2 μM) induces cell apoptosis (24 h), arrests cell cycle at G2/M phase (12 h), inhibits cell migration (48 h) and disrupts the cellular microtubule network[1]. Cell Proliferation Assay[1] Cell Line: SK-MEL-5, SK-MEL-28 and A375 Concentration: 0-100 μM Incubation Time: 48 h Result: Showed antiproliferative activity with IC50 values of 3.70 ± 0.17, 3.30 ± 0.06 and 1.98 ± 0.10 μM against SK-MEL-5, SK-MEL-28 and A375 cells, respectively. Apoptosis Analysis[1] Cell Line: SK-MEL-28 Concentration: 1 μM and 2 μM Incubation Time: 24 h Result: Induced cell apoptosis. Cell Cycle Analysis[1] Cell Line: SK-MEL-28 Concentration: 1 μM and 2 μM Incubation Time: 12 h Result: Arrested cell cycle at G2/M phase. Cell Migration Assay [1] Cell Line: SK-MEL-28 Concentration: 1 μM and 2 μM Incubation Time: 48 h Result: Inhibited cell migration. |
| References |
| Molecular Formula | C28H28N2O2 |
|---|---|
| Molecular Weight | 424.53 |