2566497-96-7
2566497-96-7 structure
- Name: Antitumor agent-68
- Chemical Name: Antitumor agent-68
- CAS Number: 2566497-96-7
- Molecular Formula: C17H11NO2
- Molecular Weight: 261.27
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2022-08-12 17:01:44
- Modify Date: 2024-01-10 08:19:25
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Antitumor agent-68 is a potent tubulin inhibitor. Antitumor agent-68 shows potent anticancer activity with IC50s of 3.6 and 3.8 µM for HeLa and MCF-7 cells, respectively. Antitumor agent-68 exhibits good scavenging activity of ROS and DPPH radical in a dose-dependent manner[1].
| Name | Antitumor agent-68 |
|---|
| Description | Antitumor agent-68 is a potent tubulin inhibitor. Antitumor agent-68 shows potent anticancer activity with IC50s of 3.6 and 3.8 µM for HeLa and MCF-7 cells, respectively. Antitumor agent-68 exhibits good scavenging activity of ROS and DPPH radical in a dose-dependent manner[1]. |
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| Related Catalog | |
| Target |
IC50: 3.6 μM (HeLa), 3.8 µM (MCF-7)[1] |
| In Vitro | Antitumor agent-68 (Compound 7) exhibits anticancer activity with IC50s of 3.6 and 3.8 μM, for HeLa and MCF-7 cells, respectively[1]. Antitumor agent-68 (10 μΜ; 24 hours) causes a 3-fold reduction of ROS production induced by Men in 3T3-L1 cells, and an EC50 of DPPH radical scavenging is 8.30 µg/mL[1]. Cell Viability Assay[1] Cell Line: HeLa, MCF-7, 3T3-L1 Concentration: 10 μM Incubation Time: 24 hours Result: Showed anticancer activity by blocking the tubulin polymerization reaction. Reduced production of ROS, and scavenged DPPH radical. |
| References |
| Molecular Formula | C17H11NO2 |
|---|---|
| Molecular Weight | 261.27 |