2485779-27-7

2485779-27-7 structure
2485779-27-7 structure
  • Name: ATX inhibitor 11
  • Chemical Name: ATX inhibitor 11
  • CAS Number: 2485779-27-7
  • Molecular Formula: C32H35N5O6
  • Molecular Weight: 585.65
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
  • Create Date: 2022-08-09 15:35:11
  • Modify Date: 2024-04-05 22:40:26
  • ATX inhibitor 11 (compound 13c) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.7 nM. ATX inhibitor 11 can typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA in mice fibrosis model. ATX inhibitor 11 can be used for lung fibrosis research[1].

Name ATX inhibitor 11
Description ATX inhibitor 11 (compound 13c) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.7 nM. ATX inhibitor 11 can typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA in mice fibrosis model. ATX inhibitor 11 can be used for lung fibrosis research[1].
Related Catalog
Target

Autotaxin:2.7 ± 1 nM (IC50)

References

[1]. Lei H, et al. Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model. Bioorg Chem. 2022 Mar;120:105590.

Molecular Formula C32H35N5O6
Molecular Weight 585.65