2485779-27-7

2485779-27-7 structure

Name: ATX inhibitor 11
Chemical Name: ATX inhibitor 11
CAS Number: 2485779-27-7
Molecular Formula: C₃₂H₃₅N₅O₆
Molecular Weight: 585.65
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2022-08-09 15:35:11
Modify Date: 2025-09-05 12:12:02
ATX inhibitor 11 (compound 13c) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.7 nM. ATX inhibitor 11 can typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA in mice fibrosis model. ATX inhibitor 11 can be used for lung fibrosis research[1].

Name	ATX inhibitor 11

Description	ATX inhibitor 11 (compound 13c) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.7 nM. ATX inhibitor 11 can typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA in mice fibrosis model. ATX inhibitor 11 can be used for lung fibrosis research[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Others
Target	Autotaxin:2.7 ± 1 nM (IC50)
References	[1]. Lei H, et al. Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model. Bioorg Chem. 2022 Mar;120:105590.

Molecular Formula	C₃₂H₃₅N₅O₆
Molecular Weight	585.65