2477725-07-6

2477725-07-6 structure

Name: B-Raf IN 7
Chemical Name: B-Raf IN 7
CAS Number: 2477725-07-6
Molecular Formula: C₁₅H₁₆N₆O₃
Molecular Weight: 328.33
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2022-08-10 17:02:01
Modify Date: 2024-01-11 16:23:21
B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC50 of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC50 values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM[1].

Name	B-Raf IN 7

Description	B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC50 of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC50 values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf
Target	B-Raf:110.23 ± 0 nM (IC50)
References	[1]. Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.

Molecular Formula	C₁₅H₁₆N₆O₃
Molecular Weight	328.33