B-Raf IN 7

Modify Date: 2024-01-11 16:23:21

B-Raf IN 7 structure	Common Name	B-Raf IN 7
	CAS Number	2477725-07-6	Molecular Weight	328.33
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₆N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of B-Raf IN 7

B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC50 of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC50 values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM[1].

Name	B-Raf IN 7

Description	B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC50 of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC50 values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf
Target	B-Raf:110.23 ± 0 nM (IC50)
References	[1]. Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.

Molecular Formula	C₁₅H₁₆N₆O₃
Molecular Weight	328.33

B-Raf IN 7

Use of B-Raf IN 7

Names

B-Raf IN 7 Biological Activity

Chemical & Physical Properties