1215313-19-1

1215313-19-1 structure

Name: B-Raf IN 8
Chemical Name: B-Raf IN 8
CAS Number: 1215313-19-1
Molecular Formula: C₁₈H₁₇N₃O₂
Molecular Weight: 307.35
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2022-08-24 16:48:25
Modify Date: 2024-09-12 18:01:42
B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC50 of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC50 values of 9.78, 13.78, 18.52 and 29.85 µM[1].

Name	B-Raf IN 8

Description	B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC50 of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC50 values of 9.78, 13.78, 18.52 and 29.85 µM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf
Target	B-Raf:70.65 ± 0. nM (IC50)
References	[1]. Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.

Molecular Formula	C₁₈H₁₇N₃O₂
Molecular Weight	307.35