2479315-19-8

2479315-19-8 structure

Name: BACE1-IN-12
Chemical Name: BACE1-IN-12
CAS Number: 2479315-19-8
Molecular Formula: C₂₉H₂₈Cl₂N₆O
Molecular Weight: 547.48
Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
Create Date: 2022-08-22 22:35:38
Modify Date: 2024-01-10 15:27:13
BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 μM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent[1].

Name	BACE1-IN-12

Description	BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 μM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
Target	IC50: 8.9 ± 0.20 µM (BACE1), 3.2 ± 0.2 µM (BuChE)[1]
References	[1]. Haghighijoo Z, et al. N-Cyclohexylimidazo[1,2-a]pyridine derivatives as multi-target-directed ligands for treatment of Alzheimer's disease. Bioorg Chem. 2020 Oct;103:104146.

Molecular Formula	C₂₉H₂₈Cl₂N₆O
Molecular Weight	547.48