2447589-08-2

2447589-08-2 structure

Name: COX-2-IN-22
Chemical Name: COX-2-IN-22
CAS Number: 2447589-08-2
Molecular Formula: C₂₉H₂₄O₇
Molecular Weight: 484.50
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-08-08 18:59:43
Modify Date: 2024-01-11 23:46:08
COX-2-IN-22 (Compound 4h) is a COX-2 inhibitor with an IC50 of 8.6 µM. COX-2-IN-22 also inhibits AChE, BChE, β-Secretase, LOX-5 and DPPH with IC50 values of 2.8, 6.3, 15.3, 13.9 and 6.8 µM, respectively. COX-2-IN-22 can cross BBB[1].

Name	COX-2-IN-22

Description	COX-2-IN-22 (Compound 4h) is a COX-2 inhibitor with an IC50 of 8.6 µM. COX-2-IN-22 also inhibits AChE, BChE, β-Secretase, LOX-5 and DPPH with IC50 values of 2.8, 6.3, 15.3, 13.9 and 6.8 µM, respectively. COX-2-IN-22 can cross BBB[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	COX-2:8.6 μM (IC50) AChE:2.8 μM (IC50) BChE:6.3 μM (IC50) β-Secretase:15.3 μM (IC50) LOX-5:13.9 μM (IC50) DPPH:6.8 μM (IC50)
References	[1]. Agbo EN, et al. Synthesis of furocoumarin-stilbene hybrids as potential multifunctional drugs against multiple biochemical targets associated with Alzheimer's disease. Bioorg Chem. 2020 Aug;101:103997.

Molecular Formula	C₂₉H₂₄O₇
Molecular Weight	484.50