76382-13-3

76382-13-3 structure

Name: Dichlorphenamide disodium
Chemical Name: Dichlorphenamide disodium
CAS Number: 76382-13-3
Molecular Formula: C₆H₆Cl₂N₂Na₂O₄S₂
Molecular Weight: 351.14
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2022-08-03 14:24:52
Modify Date: 2024-01-14 13:55:24
Dichlorphenamide disodium is an orally active, specific, carbonic anhydrase inhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research[1].

Name	Dichlorphenamide disodium

Description	Dichlorphenamide disodium is an orally active, specific, carbonic anhydrase inhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Neurological Disease
In Vivo	Dichlorphenamide disodium can reduce IOP locally in male albino rabbits[1]. Animal Model: Male albino rabbits (approximately 2.5 kg)[1] Dosage: 50 μL 10% aqueous solutions of dichlorphenamide sodium or 2 mg/kg, 6 mg/kg Administration: Eye drop of 50 μL or Oral gavage of 2 mg/kg or 6 mg/kg，5 hours Result: Showed significant decrease in IOP at 30 min by instilling into eyes and decrease in IOP only at 1 h by orally after drug administration. And demonstrated that drug levels were significantly higher in the iris ciliary body and lower in the serum by instilling compared to oral administration.
References	[1]. V J Lotti, et al. Topical ocular hypotensive activity and ocular penetration of dichlorphenamide sodium in rabbits. Graefes Arch Clin Exp Ophthalmol. 1984;222(1):13-9. doi: 10.1007/BF02133771.

Molecular Formula	C₆H₆Cl₂N₂Na₂O₄S₂
Molecular Weight	351.14