2463198-51-6

2463198-51-6 structure
2463198-51-6 structure
  • Name: HDAC-IN-40
  • Chemical Name: HDAC-IN-40
  • CAS Number: 2463198-51-6
  • Molecular Formula: C15H22N2O6
  • Molecular Weight: 326.34
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
  • Create Date: 2022-09-01 10:02:09
  • Modify Date: 2024-01-14 10:07:18
  • HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects[1].

Name HDAC-IN-40
Description HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects[1].
Related Catalog
Target

HDAC2:60 nM (Ki)

HDAC6:30 nM (Ki)

HDAC4:49200 μM (Ki)

HDAC8:5690 nM (Ki)

In Vitro HDAC-IN-40 (Compound 13d) shows antiproliferative activity against the cell line A2780 and Cal27 with IC50 values of 0.89 µM and 0.72 µM, respectively[1]. HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR[1]. HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation[1].
References

[1]. Yodita Asfaha, et al. Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells. Bioorg Med Chem. 2020 Jan 1;28(1):115108.

Molecular Formula C15H22N2O6
Molecular Weight 326.34