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2490309-83-4

2490309-83-4 structure

2490309-83-4 structure

Name: HDAC-IN-41
Chemical Name: HDAC-IN-41
CAS Number: 2490309-83-4
Molecular Formula: C₂₀H₂₂N₄O₆S
Molecular Weight: 446.48
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-09-16 11:08:02
Modify Date: 2024-01-14 07:49:22
HDAC-IN-41 (Compound 7c) is a selective, orally active class I HDAC inhibitor with IC50 values of 0.62, 1.46 and 0.62 μM against HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-41 shows NO releasing activity[1].

Name	HDAC-IN-41

Description	HDAC-IN-41 (Compound 7c) is a selective, orally active class I HDAC inhibitor with IC50 values of 0.62, 1.46 and 0.62 μM against HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-41 shows NO releasing activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1:0.62 μM (IC50) HDAC2:1.46 μM (IC50) HDAC3:0.62 μM (IC50)
In Vitro	HDAC-IN-41 (Compound 7c) shows anti-proliferative activity with IC50 values of 0.32 ± 0.06, 0.59 ± 0.09, 0.54 ± 0.05, 1.23 ± 0.06, 2.69 ± 0.15, 0.93 ± 0.08 and 1.03 ± 0.09 μM against HEL, MOLT-4, Jurkat, HeLa, PC-3, HCT116 and A549 cells, respectively[1].
In Vivo	HDAC-IN-41 (Compound 7c) (30 mg/kg/d; p.o., 15 days) inhibits tumor growth in a HCT116 xenograft model in nude mice[1].
References	[1]. Ding Q, et al. Synthesis and biological study of class I selective HDAC inhibitors with NO releasing activity. Bioorg Chem. 2020 Nov;104:104235.

Molecular Formula	C₂₀H₂₂N₄O₆S
Molecular Weight	446.48

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