2490309-83-4
2490309-83-4 structure
- Name: HDAC-IN-41
- Chemical Name: HDAC-IN-41
- CAS Number: 2490309-83-4
- Molecular Formula: C20H22N4O6S
- Molecular Weight: 446.48
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
- Create Date: 2022-09-16 11:08:02
- Modify Date: 2024-01-14 07:49:22
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HDAC-IN-41 (Compound 7c) is a selective, orally active class I HDAC inhibitor with IC50 values of 0.62, 1.46 and 0.62 μM against HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-41 shows NO releasing activity[1].
| Name | HDAC-IN-41 |
|---|
| Description | HDAC-IN-41 (Compound 7c) is a selective, orally active class I HDAC inhibitor with IC50 values of 0.62, 1.46 and 0.62 μM against HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-41 shows NO releasing activity[1]. |
|---|---|
| Related Catalog | |
| Target |
HDAC1:0.62 μM (IC50) HDAC2:1.46 μM (IC50) HDAC3:0.62 μM (IC50) |
| In Vitro | HDAC-IN-41 (Compound 7c) shows anti-proliferative activity with IC50 values of 0.32 ± 0.06, 0.59 ± 0.09, 0.54 ± 0.05, 1.23 ± 0.06, 2.69 ± 0.15, 0.93 ± 0.08 and 1.03 ± 0.09 μM against HEL, MOLT-4, Jurkat, HeLa, PC-3, HCT116 and A549 cells, respectively[1]. |
| In Vivo | HDAC-IN-41 (Compound 7c) (30 mg/kg/d; p.o., 15 days) inhibits tumor growth in a HCT116 xenograft model in nude mice[1]. |
| References |
| Molecular Formula | C20H22N4O6S |
|---|---|
| Molecular Weight | 446.48 |