2411441-54-6

2411441-54-6 structure

Name: NOD2 antagonist 1
Chemical Name: NOD2 antagonist 1
CAS Number: 2411441-54-6
Molecular Formula: C₂₆H₂₆N₄O₃S
Molecular Weight: 474.57
Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
Create Date: 2022-08-02 18:24:17
Modify Date: 2024-01-12 19:49:57
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs[1].

Name	NOD2 antagonist 1

Description	NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
Target	NOD2:5.23 μM (IC50)
References	[1]. Guzelj S, et al. Structural features and functional activities of benzimidazoles as NOD2 antagonists. Eur J Med Chem. 2020;190:112089.

Molecular Formula	C₂₆H₂₆N₄O₃S
Molecular Weight	474.57