2492376-85-7

2492376-85-7 structure

Name: PI3K/mTOR Inhibitor-8
Chemical Name: PI3K/mTOR Inhibitor-8
CAS Number: 2492376-85-7
Molecular Formula: C₂₃H₂₂N₈O₄S
Molecular Weight: 506.54
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2022-09-10 11:48:38
Modify Date: 2024-01-12 19:20:47
PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase[1].

Name	PI3K/mTOR Inhibitor-8

Description	PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	PI3Kα:0.46 nM (IC50) mTOR:12 nM (IC50)
In Vitro	PI3K/mTOR Inhibitor-8 (Compound 18b) shows anti-proliferation activities with IC50 values of 1.95 ± 0.02, 2.02 ± 0.01, 1.62 ± 0.01 and 1.55 ± 0.01 μM against PC-3, HCT-116, A549 and MDA-MB-231 cells, respectively[1].
References	[1]. Han Y, et al. Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition. Bioorg Chem. 2020 Nov;104:104197.

Molecular Formula	C₂₃H₂₂N₈O₄S
Molecular Weight	506.54