PI3K/mTOR Inhibitor-8

Modify Date: 2024-01-12 19:20:47

PI3K/mTOR Inhibitor-8 Structure
PI3K/mTOR Inhibitor-8 structure
Common Name PI3K/mTOR Inhibitor-8
CAS Number 2492376-85-7 Molecular Weight 506.54
Density N/A Boiling Point N/A
Molecular Formula C23H22N8O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PI3K/mTOR Inhibitor-8


PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase[1].

 Names

Name PI3K/mTOR Inhibitor-8

 PI3K/mTOR Inhibitor-8 Biological Activity

Description PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase[1].
Related Catalog
Target

PI3Kα:0.46 nM (IC50)

mTOR:12 nM (IC50)

In Vitro PI3K/mTOR Inhibitor-8 (Compound 18b) shows anti-proliferation activities with IC50 values of 1.95 ± 0.02, 2.02 ± 0.01, 1.62 ± 0.01 and 1.55 ± 0.01 μM against PC-3, HCT-116, A549 and MDA-MB-231 cells, respectively[1].
References

[1]. Han Y, et al. Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition. Bioorg Chem. 2020 Nov;104:104197.

 Chemical & Physical Properties

Molecular Formula C23H22N8O4S
Molecular Weight 506.54
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