2259624-71-8
2259624-71-8 structure
- Name: STING agonist-12
- Chemical Name: STING agonist-12
- CAS Number: 2259624-71-8
- Molecular Formula: C25H19ClF4N2O2
- Molecular Weight: 490.88
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2022-08-10 18:06:44
- Modify Date: 2025-08-27 16:56:12
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STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1].
| Name | STING agonist-12 |
|---|
| Description | STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 185 nM (STING)[1] |
| In Vitro | STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells[1]. STING agonist-12 is not active at mouse STING[1]. |
| In Vivo | STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life[1]. Animal Model: Balb/c mice (n=3)[1] Dosage: 5 or 10 mpk Administration: Lateral tail vein or oral gavage (Pharmacokinetic Analysis) Result: Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse[1]. Route DOSE (mpk) AUC (ng/mL*h) T1/2 (h) Cmax (ng/mL) Vd (mL/kg) F (%) IV 5 1215 1.41 1867 2689 NA PO 10 2090 NA 1723 NA 86 |
| References |
| Molecular Formula | C25H19ClF4N2O2 |
|---|---|
| Molecular Weight | 490.88 |