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2531029-88-4

2531029-88-4 structure

2531029-88-4 structure

Name: VEGFR-2-IN-21
Chemical Name: VEGFR-2-IN-21
CAS Number: 2531029-88-4
Molecular Formula: C₂₈H₂₄ClN₇O₃S
Molecular Weight: 574.05
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2022-08-18 23:44:24
Modify Date: 2024-04-09 19:49:16
VEGFR-2-IN-21 (Compound 5d) is a potent VEGFR-2 inhibitor with an IC50 of 0.10 μM. VEGFR-2-IN-21 shows anticancer activity[1].

Name	VEGFR-2-IN-21

Description	VEGFR-2-IN-21 (Compound 5d) is a potent VEGFR-2 inhibitor with an IC50 of 0.10 μM. VEGFR-2-IN-21 shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR-2:0.10 μM (IC50)
In Vitro	VEGFR-2-IN-21 (Compound 5d) shows inhibitory activities against the three HepG2, HCT116 and MCF-7 cancer cell lines with IC50 values of 8.98 ± 0.1, 7.77 ± 0.1 and 6.99 ± 0.1 µM respectively[1].
References	[1]. Saleh NM, et al. Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors. Bioorg Chem. 2020 Nov;104:104350.

Molecular Formula	C₂₈H₂₄ClN₇O₃S
Molecular Weight	574.05

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