2447597-39-7
2447597-39-7 structure
- Name: VEGFR-2-IN-28
- Chemical Name: VEGFR-2-IN-28
- CAS Number: 2447597-39-7
- Molecular Formula: C26H17N7O7
- Molecular Weight: 539.46
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-08-15 17:55:50
- Modify Date: 2025-08-25 16:02:12
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VEGFR-2-IN-28 (compound 12c) is a potent VEGFR-2 inhibitor with IC50 value of 0.83 µM. VEGFR-2-IN-28 induces apoptosis and has anticancer activity[1].
| Name | VEGFR-2-IN-28 |
|---|
| Description | VEGFR-2-IN-28 (compound 12c) is a potent VEGFR-2 inhibitor with IC50 value of 0.83 µM. VEGFR-2-IN-28 induces apoptosis and has anticancer activity[1]. |
|---|---|
| Related Catalog | |
| Target |
VEGFR-2:0.83 μM (IC50) |
| In Vitro | VEGFR-2-IN-28 (compound 12c) (24 hours; MCF-7 cells) has anticancer activity with IC50 value of 16.50 µM[1]. VEGFR-2-IN-28 (compound 12c) (24 hours; MCF-7 cells) prompts pre-G1 apoptosis, cell growth cessation at G2/M phase and induces apoptosis via activation of caspase-3[1]. Apoptosis Analysis[1] Cell Line: MCF-7 cells Concentration: 16.50 µM Incubation Time: 24 hours Result: Induced apoptotic cells resulting in apoptosis percentage 28.41 %. Cell Cycle Analysis[1] Cell Line: MCF-7 cells Concentration: 16.50 µM Incubation Time: 24 hours Result: Increased in the percentage of cells at pre-G1 phase and at G2/M phase to 28.41% and 46.05%, respectively. Immunofluorescence[1] Cell Line: MCF-7 cells Concentration: 16.50 µM Incubation Time: 24 hours Result: Increased in the level of caspase-3. |
| References |
| Molecular Formula | C26H17N7O7 |
|---|---|
| Molecular Weight | 539.46 |