2246364-63-4

2246364-63-4 structure
2246364-63-4 structure
  • Name: β-Glucuronide-dPBD-PEG5-NH2 TFA
  • Chemical Name: β-Glucuronide-dPBD-PEG5-NH2 TFA
  • CAS Number: 2246364-63-4
  • Molecular Formula: C80H102F3N7O37
  • Molecular Weight: 1810.69
  • Catalog: Research Areas Cancer
  • Create Date: 2022-08-24 15:07:29
  • Modify Date: 2024-07-16 17:19:52
  • β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a prodrug of cIRCR201-dPBD, reduces side effects[1].

Name β-Glucuronide-dPBD-PEG5-NH2 TFA
Description β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a prodrug of cIRCR201-dPBD, reduces side effects[1].
Related Catalog
Target

Drug-linker conjugates for ADC, Apoptosis[1]

References

[1]. Byeongkwi Min, et al. cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors. ACS Omega. 2020 Sep 29;5(40):25798-25809.

Molecular Formula C80H102F3N7O37
Molecular Weight 1810.69