β-Glucuronide-dPBD-PEG5-NH2 TFA

Modify Date: 2024-07-16 17:19:52

β-Glucuronide-dPBD-PEG5-NH2 TFA Structure
β-Glucuronide-dPBD-PEG5-NH2 TFA structure
Common Name β-Glucuronide-dPBD-PEG5-NH2 TFA
CAS Number 2246364-63-4 Molecular Weight 1810.69
Density N/A Boiling Point N/A
Molecular Formula C80H102F3N7O37 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of β-Glucuronide-dPBD-PEG5-NH2 TFA


β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a prodrug of cIRCR201-dPBD, reduces side effects[1].

 Names

Name β-Glucuronide-dPBD-PEG5-NH2 TFA

 β-Glucuronide-dPBD-PEG5-NH2 TFA Biological Activity

Description β-Glucuronide-dPBD-PEG5-NH2 TFA is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2 TFA, as a prodrug of cIRCR201-dPBD, reduces side effects[1].
Related Catalog
Target

Drug-linker conjugates for ADC, Apoptosis[1]

References

[1]. Byeongkwi Min, et al. cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors. ACS Omega. 2020 Sep 29;5(40):25798-25809.

 Chemical & Physical Properties

Molecular Formula C80H102F3N7O37
Molecular Weight 1810.69