2772655-86-2

2772655-86-2 structure

Name: CB1/2 agonist 3
Chemical Name: CB1/2 agonist 3
CAS Number: 2772655-86-2
Molecular Formula: C₂₅H₄₁NO₂
Molecular Weight: 387.60
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2022-09-02 10:05:20
Modify Date: 2024-01-12 10:37:40
CB1/2 agonist 3 (compound 52), a potent non-selective cannabinoid ligand, is a CB1/CB2 (cannabinoid receptor) competitive agonist. CB1/2 agonist 3 acts on hCB1 and hCB2 with Ki values of 5.9 nM and 3.5 nM, respectively[1].

Name	CB1/2 agonist 3

Description	CB1/2 agonist 3 (compound 52), a potent non-selective cannabinoid ligand, is a CB1/CB2 (cannabinoid receptor) competitive agonist. CB1/2 agonist 3 acts on hCB1 and hCB2 with Ki values of 5.9 nM and 3.5 nM, respectively[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	hCB1-R:5.9 nM (Ki) hCB2-R:3.5 nM (Ki)
In Vitro	CB1/2 agonist 3 (compound 52) can partially induce [35S]GTPγS binding to hCB1-CHO cell membranes with an EC50 value of 30.99 nM, and slightly inhibit [35S]GTPγS binding to hCB2-CHO cell membranes with a mean EC50 value of 1.28 nM[1]. CB1/2 agonist 3 (compound 52) ((1 μM, 1 h) has antagonistic effect on CB1/CB2 agonist CP-55940 with a Kb value of 78.17 nM[1].
References	[1]. Antonella Brizzi, et al. Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity. Bioorg Med Chem. 2020 Jun 1;28(11):115513.

Molecular Formula	C₂₅H₄₁NO₂
Molecular Weight	387.60