334668-69-8

334668-69-8 structure

Name: CB1R antagonist 1
Chemical Name: CB1R antagonist 1
CAS Number: 334668-69-8
Molecular Formula: C₁₈H₂₃F₃N₂O₃S
Molecular Weight: 404.45
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2022-09-16 09:37:56
Modify Date: 2024-04-06 16:37:24
CB1R Allosteric modulator 5, a novel1-sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC50 value of 4.2 μM and EC50 value of ＞10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity[1].

Name	CB1R antagonist 1

Description	CB1R Allosteric modulator 5, a novel1-sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC50 value of 4.2 μM and EC50 value of ＞10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	hCB1-R:4.2 μM (IC50) hCB1-R:10 μM (EC50)
In Vitro	CB1R Allosteric modulator 5 has cannabinoid-1 receptor (CB1R) activity with an IC50value of 4.2 μM and EC50 value of ＞10 μM[1].
References	[1]. Petr Vachal, et al. 1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity. J Med Chem. 2009 Apr 23;52(8):2550-8

Molecular Formula	C₁₈H₂₃F₃N₂O₃S
Molecular Weight	404.45