2573775-59-2

2573775-59-2 structure

2573775-59-2 structure

Name: Cbl-b-IN-3
Chemical Name: Cbl-b-IN-3
CAS Number: 2573775-59-2
Molecular Formula: C₃₀H₃₄F₃N₅O
Molecular Weight: 537.62
Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
Create Date: 2022-09-01 07:59:18
Modify Date: 2023-02-03 23:09:57
Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation[1].

Name	Cbl-b-IN-3

Description	Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme
Target	IC50: < 1 nM (Cbl-b)[1]
In Vitro	Cbl-b-IN-3 (Compound 23) enhances IL-2 secretion by T-cells stimulated with an anti-CD3 antibody alone or in combination with an anti-CD28 antibody[1].
References	[1]. Arthur T. Sands, et al. Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof. WO2020264398A1.

Molecular Formula	C₃₀H₃₄F₃N₅O
Molecular Weight	537.62