2649120-22-7

2649120-22-7 structure

2649120-22-7 structure

Name: CDK4/6-IN-8
Chemical Name: CDK4/6-IN-8
CAS Number: 2649120-22-7
Molecular Formula: C₁₈H₁₈N₆O₅
Molecular Weight: 398.37
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-08-31 12:53:08
Modify Date: 2024-01-14 15:28:01
CDK4/6-IN-8 (Compound 7p) is a selective CDK4 and CDK6 inhibitor with IC50 values of 5.01 nM and 3.97 nM, respectively[1].

Name	CDK4/6-IN-8

Description	CDK4/6-IN-8 (Compound 7p) is a selective CDK4 and CDK6 inhibitor with IC50 values of 5.01 nM and 3.97 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK4:5.01 nM (IC50) CDK6:3.97 nM (IC50)
In Vitro	CDK4/6-IN-8 (Compound 7p) (0-656.1 µM, 48 h) shows anti-breast cancer activity[1]. Cell Viability Assay[1] Cell Line: MCF-7 Concentration: 0.1, 0.3, 0.9, 2.7, 8.1, 24.3, 72.9, 218.7 and 656.1 µM Incubation Time: 48 h Result: Inhibited cell viability with an IC50 of 2.8 μM.
References	[1]. Liang JW, et al. Synthesis and identification of a novel skeleton of N-(pyridin-3-yl) proline as a selective CDK4/6 inhibitor with anti-breast cancer activities. Bioorg Chem. 2022 Feb;119:105547.

Molecular Formula	C₁₈H₁₈N₆O₅
Molecular Weight	398.37