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2413565-18-9

2413565-18-9 structure

2413565-18-9 structure

Name: COX-2-IN-28
Chemical Name: COX-2-IN-28
CAS Number: 2413565-18-9
Molecular Formula: C₃₀H₂₇N₇S₃
Molecular Weight: 581.78
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-09-04 15:29:39
Modify Date: 2024-04-09 10:05:57
COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC50 values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively[1].

Name	COX-2-IN-28

Description	COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC50 values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1:13.21 μM (IC50) COX-2:0.054 μM (IC50) 15-LOX:2.14 μM (IC50)
In Vitro	COX-2-IN-28 (compound 15c) shows significant COX-2 selectivity with an SI value of 244.63[1].
References	[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

Molecular Formula	C₃₀H₂₇N₇S₃
Molecular Weight	581.78

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