2580941-45-1

2580941-45-1 structure

Name: Estrogen receptor α antagonist 1
Chemical Name: Estrogen receptor α antagonist 1
CAS Number: 2580941-45-1
Molecular Formula: C₂₆H₃₂N₂O₅
Molecular Weight: 452.54
Catalog: Research Areas Cancer
Create Date: 2022-09-18 22:36:00
Modify Date: 2024-09-18 17:15:02
Estrogen receptor α antagonist 1 (compound 35) is a highly selective antagonist of estrogen receptor α, with IC50s of 0.02, 6.55 and 7.73 μM for estrogen receptor α, estrogen receptor β and MCF-7 cells, respectively. Estrogen receptor α antagonist 1 (compound 35) can be used for the research of cancer[1].

Name	Estrogen receptor α antagonist 1

Description	Estrogen receptor α antagonist 1 (compound 35) is a highly selective antagonist of estrogen receptor α, with IC50s of 0.02, 6.55 and 7.73 μM for estrogen receptor α, estrogen receptor β and MCF-7 cells, respectively. Estrogen receptor α antagonist 1 (compound 35) can be used for the research of cancer[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
Target	IC50: 0.02 μM (Estrogen receptor α), 6.55 μM (Estrogen receptor β) and 7.73 μM (MCF-7 cells)[1]
In Vitro	Estrogen receptor α antagonist 1 (compound 35) (1 nM-100 μM; 72 h)selectively inhibites estrogen receptor α, estrogen receptor β and MCF-7 cells[1]. Cell Viability Assay[1] Cell Line: MCF-7 cells Concentration: 1 nM-100 μM Incubation Time: 72 hours Result: Exhibited IC50s of 0.02, 6.55 and 7.73 μM for estrogen receptor α, estrogen receptor β and MCF-7 cells, respectively at 72 hours.
References	[1]. Carr M, et al. Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening. Bioorg Med Chem. 2020 Mar 1;28(5):115261.

Molecular Formula	C₂₆H₃₂N₂O₅
Molecular Weight	452.54