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1042433-41-9

1042433-41-9 structure
1042433-41-9 structure
  • Name: GSK-1520489A
  • Chemical Name: GSK-1520489A
  • CAS Number: 1042433-41-9
  • Molecular Formula: C21H23N5O3S
  • Molecular Weight: 425.50
  • Catalog: Research Areas Cancer
  • Create Date: 2022-09-16 13:39:20
  • Modify Date: 2024-01-12 18:16:21
  • GSK-1520489A is a PKMYT1 (active protein kinase) inhibitor (IC50=115 nM, Ki=10.94 nM)[1].
Name GSK-1520489A
Description GSK-1520489A is a PKMYT1 (active protein kinase) inhibitor (IC50=115 nM, Ki=10.94 nM)[1].
Related Catalog
Target

IC50: 115 nM (PKMYT1)[1]

In Vitro GSK-1520489A (4 µM, 24 h) treatment shows inhibition of phosphorylation of Tyr15 in Cdk1[1]. Western Blot Analysis[1] Cell Line: HT29 cells Concentration: 4 µM Incubation Time: 24 hours Result: Reduced Cdk1-phosphorylation at tyrosine in comparison to the uninhibited reaction.
References

[1]. Charlott Platzer, et al. Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. Bioorg Med Chem. 2018 Aug 7;26(14):4014-4024.
Molecular Formula C21H23N5O3S
Molecular Weight 425.50
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title: CAS No. 1042433-41-9 | Chemsrc address: https://m.chemsrc.com/en/baike/1713727.html

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