GSK-1520489A
Modify Date: 2025-08-25 16:34:22
GSK-1520489A structure
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Common Name | GSK-1520489A | ||
|---|---|---|---|---|
| CAS Number | 1042433-41-9 | Molecular Weight | 425.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H23N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GSK-1520489AGSK-1520489A is a PKMYT1 (active protein kinase) inhibitor (IC50=115 nM, Ki=10.94 nM)[1]. |
| Name | GSK-1520489A |
|---|
| Description | GSK-1520489A is a PKMYT1 (active protein kinase) inhibitor (IC50=115 nM, Ki=10.94 nM)[1]. |
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| Related Catalog | |
| Target |
IC50: 115 nM (PKMYT1)[1] |
| In Vitro | GSK-1520489A (4 µM, 24 h) treatment shows inhibition of phosphorylation of Tyr15 in Cdk1[1]. Western Blot Analysis[1] Cell Line: HT29 cells Concentration: 4 µM Incubation Time: 24 hours Result: Reduced Cdk1-phosphorylation at tyrosine in comparison to the uninhibited reaction. |
| References |
| Molecular Formula | C21H23N5O3S |
|---|---|
| Molecular Weight | 425.50 |
| InChIKey | AKHLCKMEVWGDGL-UHFFFAOYSA-N |
| SMILES | CNC(=O)c1ccccc1Nc1nc(Nc2cccc(CS(C)(=O)=O)c2)ncc1C |