1818864-51-5

1818864-51-5 structure

1818864-51-5 structure

Name: MC-VA-PABC-MMAE
Chemical Name: MC-VA-PABC-MMAE
CAS Number: 1818864-51-5
Molecular Formula: C₆₅H₉₉N₉O₁₄
Molecular Weight: 1230.53
Catalog: Research Areas Cancer
Create Date: 2022-09-29 21:32:12
Modify Date: 2024-01-13 21:43:30
MC-VA-PABC-MMAE is a drug-linker conjugate for ADC. MC-VA-PABC-MMAE contains the ADCs linker (peptide MC-VA-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162)[1][2].

Name	MC-VA-PABC-MMAE

Description	MC-VA-PABC-MMAE is a drug-linker conjugate for ADC. MC-VA-PABC-MMAE contains the ADCs linker (peptide MC-VA-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162)[1][2].
Related Catalog	Research Areas >> Cancer
Target	Auristatin
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References	[1]. Wang Y, et al. Development of applicable thiol-linked antibody-drug conjugates with improved stability and therapeutic index. Drug Deliv. 2022 Dec;29(1):754-766. [2]. Cazzamalli S, et al. Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma. J Control Release. 2017 Jan 28;246:39-45.

Molecular Formula	C₆₅H₉₉N₉O₁₄
Molecular Weight	1230.53