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2091950-43-3

2091950-43-3 structure

2091950-43-3 structure

Name: Multi-kinase-IN-3
Chemical Name: Multi-kinase-IN-3
CAS Number: 2091950-43-3
Molecular Formula: C₃₃H₃₃N₅O₃
Molecular Weight: 547.65
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK PDGFR
Create Date: 2022-08-31 20:26:29
Modify Date: 2025-08-26 14:47:00
Multi-kinase-IN-3 (compound 2) is a potent angiokinase inhibitor. Multi-kinase-IN-3 shows inhibition activity against VEGFR-2 and PDGFRβ, with IC50 values of 58.3 and 55 nM, respectively[1].

Name	Multi-kinase-IN-3

Description	Multi-kinase-IN-3 (compound 2) is a potent angiokinase inhibitor. Multi-kinase-IN-3 shows inhibition activity against VEGFR-2 and PDGFRβ, with IC50 values of 58.3 and 55 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	PDGFRβ:55 ± 2.6 nM (IC50) VEGFR-2:58.3 ± 5.9 nM (IC50)
References	[1]. Qin M, et al. Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity. Bioorg Med Chem. 2020 Jun 1;28(11):115486.

Molecular Formula	C₃₃H₃₃N₅O₃
Molecular Weight	547.65

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