Multi-kinase-IN-3

Modify Date: 2024-07-20 19:57:29

Multi-kinase-IN-3 Structure
Multi-kinase-IN-3 structure
Common Name Multi-kinase-IN-3
CAS Number 2091950-43-3 Molecular Weight 547.65
Density N/A Boiling Point N/A
Molecular Formula C33H33N5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Multi-kinase-IN-3


Multi-kinase-IN-3 (compound 2) is a potent angiokinase inhibitor. Multi-kinase-IN-3 shows inhibition activity against VEGFR-2 and PDGFRβ, with IC50 values of 58.3 and 55 nM, respectively[1].

 Names

Name Multi-kinase-IN-3

 Multi-kinase-IN-3 Biological Activity

Description Multi-kinase-IN-3 (compound 2) is a potent angiokinase inhibitor. Multi-kinase-IN-3 shows inhibition activity against VEGFR-2 and PDGFRβ, with IC50 values of 58.3 and 55 nM, respectively[1].
Related Catalog
Target

PDGFRβ:55 ± 2.6 nM (IC50)

VEGFR-2:58.3 ± 5.9 nM (IC50)

References

[1]. Qin M, et al. Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity. Bioorg Med Chem. 2020 Jun 1;28(11):115486.

 Chemical & Physical Properties

Molecular Formula C33H33N5O3
Molecular Weight 547.65